Dev119685 1..11
نویسندگان
چکیده
Regeneration requires that the identities of new cells are properly specified to replace missing tissues. The Wnt signaling pathway serves a central role in specifying posterior cell fates during planarian regeneration. We identified a gene encoding a homolog of the Teashirt family of zinc-finger proteins in the planarian Schmidtea mediterranea to be a target of Wnt signaling in intact animals and at posterior-facing wounds. Inhibition of Smed-teashirt (teashirt) by RNA interference (RNAi) resulted in the regeneration of heads in place of tails, a phenotype previously observed with RNAi of the Wnt pathway genes β-catenin-1, wnt1, Dvl-1/2 or wntless. teashirt was required for β-catenin-1-dependent activation of posterior genes during regeneration. These findings identify teashirt as a transcriptional target of Wnt signaling required for Wnt-mediated specification of posterior blastemas.
منابع مشابه
Dev119685 1062..1072
Regeneration requires that the identities of new cells are properly specified to replace missing tissues. The Wnt signaling pathway serves a central role in specifying posterior cell fates during planarian regeneration. We identified a gene encoding a homolog of the Teashirt family of zinc-finger proteins in the planarian Schmidtea mediterranea to be a target of Wnt signaling in intact animals ...
متن کاملLine 806 (06/25/17) -- Metro Rail - Downtown LA - Downtown Santa Monica
— — — 3:26A 3:29A 3:31A 3:35A 3:37A 3:39A 3:41A 3:42A 3:44A 3:48A 3:51A 3:53A 3:55A 3:58A 4:04A 4:06A — — — 3:47 3:50 3:52 3:56 3:58 4:00 4:02 4:03 4:05 4:09 4:12 4:14 4:16 4:19 4:25 4:27 — — — 3:59 4:02 4:04 4:08 4:10 4:12 4:14 4:15 4:17 4:21 4:24 4:26 4:28 4:31 4:37 4:39 — — — 4:11 4:14 4:16 4:20 4:22 4:24 4:26 4:27 4:29 4:33 4:36 4:38 4:40 4:43 4:49 4:51 — — — 4:26 4:29 4:31 4:35 4:37 4:39 4...
متن کاملLine 803 (12/11/16) -- Metro Rail - Metro Green Line - RailEastbound to Norwalk - Westbound to Redondo Beach
— — — — — — — — — — 3:36A 3:42A 3:58A 4:08A — 3:53A 3:55A 3:57A 3:59A 4:02A 4:05A 4:07A 4:09A 4:11A 4:13 4:16 4:21 4:25 — 4:21 4:23 4:25 4:27 4:30 4:33 4:35 4:37 4:39 4:41 4:44 4:49 4:53 4:31A 4:33 4:35 4:37 4:39 4:42 4:45 4:47 4:49 4:51 5:00 5:03 5:08 5:12 4:50 4:52 4:54 4:56 4:58 5:01 5:04 5:06 5:08 5:10 5:12 5:15 5:20 5:24 5:03 5:05 5:07 5:09 5:11 5:14 5:17 5:19 5:21 5:23 5:25 5:28 5:33 5:37...
متن کاملLine 804 (06/26/16) -- Metro Rail - Metro Gold Line (Azusa – Union Station – East LA)
4:20A 4:30A 4:34A 4:40A 4:44A 4:50A 4:56A 4:59A 5:04A 5:05A 5:09A 5:12A 5:17A 5:20A 5:24A 5:28A 5:32A 4:44 4:54 4:58 5:04 5:08 5:14 5:20 5:23 5:28 5:29 5:33 5:36 5:41 5:44 5:48 5:52 5:56 5:04 5:14 5:18 5:24 5:28 5:34 5:40 5:43 5:48 5:49 5:53 5:56 6:01 6:04 6:08 6:12 6:16 5:24 5:34 5:38 5:44 5:48 5:54 6:00 6:03 6:08 6:09 6:13 6:16 6:21 6:24 6:28 6:32 6:36 5:44 5:54 5:58 6:04 6:08 6:14 6:20 6:23 ...
متن کامل11 - Hydroxysteroid dehydrogenase type 1 is a predominant 11 - reductase in the intact perfused rat liver
11 -Hydroxysteroid dehydrogenase type 1 (11 -HSD-1), a regulator of intrahepatocellular glucocorticoid activity, is bidirectional in homogenates but catalyses 11 reduction (regenerating glucocorticoid) in intact primary hepatocytes in culture. To examine this discrepancy at the whole-organ level, we examined 11 -HSD-1 activity in the intact bivascularly perfused rat liver. On a single pass thro...
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